|
KMID : 1134120160190020218
|
|
Journal of Breast Cancer
2016 Volume.19 No. 2 p.218 ~ p.221
|
|
|
Experience with Bilateral Risk-Reducing Mastectomy for an Unaffected BRCA Mutation Carrier
|
|
Yurina Maeshima
Kumiko Oseto
Ryohei Katsuragi
Yukiko Yoshimoto
Sachiko Takahara
Akira Yamauchi
|
|
|
Abstract
|
|
|
|
Women with BRCA1/2 mutations have a high risk of breast cancer and may opt for risk-reducing mastectomy (RRM). We report a 38-year-old Japanese woman who was diagnosed as a BRCA2 mutation carrier. She underwent prophylactic bilateral skin-sparing mastectomy (SSM) with excision of the nipple and preservation of the areola skin. It is unclear whether a bilateral RRM leads to better survival compared with intensive surveillance. The oncological risk associated with the presence of remnant breast glandular tissue after SSM or nipple-sparing mastectomy has been obscure. We report the first case of RRM for a Japanese BRCA mutation carrier and provide a literature review on risk management for BRCA mutation carriers with a focus on the concepts and procedures of RRM.
|
|
|
KEYWORD
|
|
|
Genes, BRCA2, Prophylactic surgical procedure, Subcutaneous mastectomy
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
   
|